Research
Excellence in Research through National and International Collaborations
GMI: Where Compassion Drives Innovation
The mission of the German Medical Institute (GMI) is to deliver expert, patient-centred healthcare, provide first-class medical education, and conduct ground-breaking scientific research. Research is an integral pillar of our work—fueling our fight against complex medical conditions in Cyprus, across Europe, and globally.
Our team includes dedicated scientists and physicians who work tirelessly to transform medical challenges into opportunities for progress. At GMI, compassion drives innovation. We believe that listening to our patients—both to what is said and what remains unspoken—guides us toward meaningful, personalized care and fuels the development of new, targeted medical solutions.
Hospital and Research Center Under One Roof
GMI is uniquely positioned as both a hospital and a research centre, enabling a seamless flow between clinical insight and scientific discovery. This model minimizes the time between research breakthroughs and their application in patient care. Physicians who intimately understand the needs of their patients work closely with scientists who turn those needs into focused, patient-driven research initiatives.
This collaborative culture, grounded in interdisciplinary teamwork, sets GMI apart—empowering us to tackle challenging medical problems with original and effective solutions.
National and International Collaborations
Our researchers are engaged in collaborative projects with several renowned institutions in Cyprus, Europe, and the United States. The research conducted at GMI is internationally recognized and largely supported by competitive grants from the Cyprus Research and Innovation Foundation and the European Union.
Through excellence in research and a deeply human approach to care, we are committed to shaping the future of medicine and improving lives—one patient at a time.
The GMI brings translational and clinical research together in a single location
Translational Research
At the German Medical Institute, translational research bridges the gap between laboratory discoveries and clinical application—bringing innovative ideas from bench to bedside, while also using clinical observations to inform laboratory research (bedside to bench). This dynamic, bidirectional approach ensures that every research project directly addresses real-world patient needs and accelerates the pace of medical innovation.
A Multidisciplinary Approach to Innovation
Translational research at GMI is driven by multidisciplinary teams, including physicians, biologists, physicists, and computer engineers. This collaborative framework enables us to tackle complex challenges from multiple scientific perspectives and to develop comprehensive, patient-centred solutions.
Key Research Areas
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Molecular Research
Our molecular teams focus on identifying new biomarkers in blood and tissue samples. These discoveries lay the groundwork for personalized and individualized treatment plans, tailored to the unique biological profile of each patient. -
Technical and Engineering Research
Our technical teams develop cutting-edge artificial intelligence tools for medical image processing, work on novel imaging modalities and techniques, and contribute to high-precision radiotherapy innovations, all designed to enhance diagnostic accuracy and treatment outcomes.
Impact and Purpose
Each project is carefully designed to be scientifically rigorous and clinically relevant, with the goal of delivering new and effective therapies to our patients as quickly and safely as possible. Our mission is to ensure that medical breakthroughs are translated into practice without delay—improving lives through the power of science.
List of our collaborators in Translational Research
Biobank of the Cyprus University
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GMI will act as a satellite facility of the Biobank contributing to the sample collection that will be available for research purposes.
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Partners in various research projects.
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Link: biobank.cy
Dr. Sylianopoullos Triantafyllos, associate professor at the Department of Mechanical and Manufacturing Engineering of the University of Cyprus
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Projects related to the exploration of mechanopathology of cancer.
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Partners in a project aiming to investigate biomarkers of breast tumors for the early prediction of patients’ response to treatment.
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Link: ucy.ac.cy
Dr. Damianou Christakis, professor at the Department of Electrical Engineering, Computer Engineering and Informatics of the Cyprus University of Technology
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Various projects related to the therapeutic application of focused ultrasound.
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Partners in SoundPet research program which is funded from Cyprus Research & Innovation Foundation. SoundPet aim is to develop an MRI-guided focused ultrasound system for cancer.
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Link: cut.ac.cy
Clinical Research
Clinical Research and Personalized Medicine at GMI
At the German Medical Institute, our clinical research efforts are at the forefront of innovation, driving forward the development of personalized diagnosis, treatment, and patient care. Through the work of our dedicated Clinical Trials Unit, we aim to bring the latest and most advanced medications and medical technologies directly to those who need them.
A Multidisciplinary Team Focused on Innovation and Compassion
Our Clinical Trials Unit is staffed by a specialized team of physicians and research nurses who are committed to improving care through science. Their work focuses on two key areas:
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Conducting early- and late-phase clinical trials, providing patients access to promising therapies before they are widely available.
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Empowering patients, by involving them in treatment decisions and ensuring their experiences, preferences, and values are integrated into care planning.
Personalized Care Beyond the Diagnosis
The research team is committed to fully individualized treatment, going beyond generic disease protocols. Personalization is based not only on the biological and molecular profile of the disease, but also on the specific trajectory of each patient's condition.
Our clinical research projects address both diagnostic and therapeutic stages, and also explore the ethical and psychological dimensions of patient care. This holistic approach ensures that innovation is matched by empathy, and that treatment is as human as it is advanced.
List of our collaborators in Clinical Research
Europa Donna Cyprus
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Partners in research activities related to palliative/supportive care and sexuality issues.
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Link: europadonna.com.cy
Europa Uomo Cyprus
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Partners in research activities related to prostate cancer.
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Link: europauomocyprus.com.cy
Ongoing clinical trials
Why should you take part in a clinical trial at the German Medical Institute?
At the German Medical Institute (GMI), our patients' needs are always at the heart of everything we do. This deep sense of compassion fuels our commitment to medical innovation—innovation that aims to help patients live longer, healthier, and more fulfilling lives.
Through controlled research studies, known as prospective clinical trials, we offer access to cutting-edge therapies, diagnostics, and treatment options that go beyond the scope of standardized care. Participation in these trials not only offers potential benefits to individual patients but also contributes to medical advancements that can help future generations.
A Patient-Centred Approach to Research
At GMI, we believe that meaningful research begins by listening. Before launching any clinical trial, we consult with local and international patient advocacy organizations to ensure that the study reflects what patients truly need and value. This collaborative approach strengthens the ethical foundation of our work and ensures that our research remains aligned with the real-life concerns of those we serve.
By combining scientific excellence with human understanding, we are proud to lead research that puts people first.
The German Medical Institute offers:
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Enrolling in a clinical trial at the German Medical Institute offers patients access to exceptional opportunities that extend beyond standard care. Benefits include:
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Convenient access to leading-edge clinical trials, featuring some of today’s most promising advancements in diagnostics and treatment.
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Availability of alternative therapies and experimental drugs not yet widely accessible through conventional healthcare channels.
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A chance to play an active role in your healthcare, contributing to the development of future treatments while exploring additional options for your own condition.
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Participation in patient empowerment studies, conducted in collaboration with patient advocacy groups and internationally recognized experts in the field—ensuring that your voice and experience directly shape the future of care.
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At GMI, clinical trials are not just research—they are pathways to hope, healing, and progress.
Through clinical trials, researchers gain a deeper understanding of how to diagnose, treat and prevent diseases and medical conditions. These research studies test and compare experimental medications and techniques to learn everything necessary before offering these new beneficial medical procedures or medications to patients. In fact, most medications and devices which are used today began in clinical trials that tested their safety and effectiveness.
Clinical trials, and the patients who volunteer to take part in them, help shape the future of medicine. Yet applying to participate in a clinical trial is a personal decision—and one that you should consider carefully. As you weigh your decision, consider these key questions:
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What is the purpose of the specific research study?
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Who will be in charge of my care?
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What will happen to me during the study?
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Will the research benefit me personally?
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How might this study affect my daily life?
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Will there be any known side effects?
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How will I know if the experimental treatment is working?
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Are there other options?
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Can I leave the research study at any point?
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Will I be provided with the results of the study?
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How is my safety ensured and protected?
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Will it cost me anything?
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Will this be covered by my insurance?
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A dedicated board, made up of GMI researchers, carefully reviews all potential clinical trials. Before making a trial available to patients, each trial is discussed and approved by patient representative organizations, the local ethics committee, and local legal authorities. However, it is important that you understand the potential benefits and risks of taking part in any research study, which include:
Benefits
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Helping test investigational medications and treatments that may develop into a better treatment option for people around the world
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Playing an active role in your own healthcare
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Gaining access to new research treatments before they are available to the public
Risks
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Possible unpleasant, serious, or life-threatening side effects related to the specific experimental treatment
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Treatments, diagnostic approaches, or therapies may not be effective
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Protocols may require more time and attention than standard care, including trips to the study site, additional treatments, hospital stays or complex dosage requirements
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List of Ongoing Clinical Trials
Below you can find our ongoing clinical trials linked to the diseases they are targeting:
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A multinational, non-interventional, prospective study of Nivolumab (BMS-936558) in patients with locally advanced or metastatic (STAGE IIIB-IV) non-small cell lung cancer (NSCLC) with squamous and non-squamous histology after prior chemotherapy treated in real world settings in Greece and Cyprus. (funded by Bristol Myers)
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Image-guided focal dose escalation in patients with primary prostate cancer treated with primary external beam hypofractionated stereotactic radiation therapy (HypoFocal-SBRT) – a prospective, multicenter, randomized phase III study (funded by the German Federal Ministry Education and Research)
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In the Agora3.0 project a multidisciplinary team of researchers from Cyprus and abroad is testing novel artificial intelligence-based health tools to improve the outcomes and the quality of life for patients suffering from various diseases (e.g. prostate cancer, breast cancer and rectal cancer). This project is funded by the Cypriot Research and Innovation Foundation. Please see the homepage (https://www.agora3.com.cy/) for more information.
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The prospective, single-arm phase II HypoCombi trial examines the application of high-precision radiotherapy in terms of brachytherapy in combination with the most modern medical imaging techniques in terms of PSMA-PET and MRI in patients with newly diagnosed prostate cancer (internal founding).
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MEDISKIN project, a partnership with RSL Revolutionary laboratories and Cyprus University of Technology aiming in the optimisation of the quality of life for patients with breast cancer and head and neck cancer undergoing radiotherapy. In this placebo-controlled study, we examine if the application of a novel medical-grade skin care product helps to prevent radiation-induced skin injuries (funded by the Cypriot Research and Innovation Foundation)
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Development of novel medical-grade skincare products for oncology patients.
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Funded by the Cyprus Research & Innovation Foundation
Research Projects
The GMI research teams have been recognised internationally for their expertise in a large number of projects.
The GMI, with its partners, is associated with the most ambitious scientific projects in Europe, and internationally. The GMI team tackles cutting edge research fields including the implementation of artificial intelligence tools for medical imaging processing, and the search for novel biomarkers which will help make treatment individualised.
Research Project Manager
Kristis Vevis
Through clinical trials, researchers gain a deeper understanding of how to diagnose, treat and prevent diseases and medical conditions. These research studies test and compare experimental medications and techniques to learn everything necessary before offering these new beneficial medical procedures or medications to patients. In fact, most medications and devices which are used today began in clinical trials that tested their safety and effectiveness.
Transition Project
The TRANSiTION project will develop an advanced education programme for healthcare professionals and non-clinical staff (i.e. health managers), equipping them with digital skills needed to exchange information more efficiently and effectively with patients and other professionals. The project will begin by assessing and mapping the current digital skills and will engage directly with stakeholders to identify their specific needs. This will enable and facilitate professionals and non-clinical staff to adopt new digital tools and integrate them into their everyday practices enabling a smoother digital transition.
Official Website Link: www.europeancancer.org/eu-projects/resource/transition
SELAS-VIEW: An integrated solution for monitoring of progression of metastasis in lung cancer
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BIOS (Digital Skills on Computational Biology for Health Professionals – Erasmus+) https://www.bios-project.eu/
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SpectThyroid (Optimizing the diagnostic value of postsurgical I-123 SPECT thyroid imaging and applying patient-specific dosimetry for radioiodine ablation of thyroid remnants – Cyprus Research & Innovation Foundation)
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SARCOSONIC (Pre-Clinical And Veterinary Research Using MRgFUS For The Treatment Of Soft-Tissue Sarcoma – H2020 programme, Marie Sklodowska Curie Actions)
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eCAN (Joint Action on strengthening e-health including telemedicine and remote monitoring for health care systems for cancer prevention and care – EU4HELATH)
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Contact Details
ADDRESS
1, Nikis Avenue,
4108, Agios Athanasios,
Limassol, Cyprus
PHONE
(+357) 25 208 000
WORKING HOURS
Mon - Fri: 08:00 - 16:30
