· Head of Electrophysiology and Complex Cardiac Devices, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK

· Director of the Intracardiac Echocardiography Training Course at The Northern General

Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK

·   Consultant Cardiologist with a Specialist Interest in Electrophysiology and Complex Cardiac Devices at The Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK

·   Honorary Senior Lecturer, The University of Sheffield, UK

• October 2013 – June 2015: Electrophysiology and Complex Devices Fellow (SpR Year 5 and 6), Royal Brompton and Harefield Hospitals NHS Foundation Trust

• May 2015 – December 2015: Medtronic CRHF University Programme, 2015

• September 2013 - June 2014; Meet the Masters Fellows Programme- Programme Director, Professor Pedro Brugada

• January 2012 to October 2013: Electrophysiology and Complex Devices Fellow (SpR year 4 and 5), Imperial College Healthcare NHS Trust

• Honorary Clinical Research Fellow, Imperial College, London (2012- 2015)

• January 2009 to January 2012: Cardiology Clinical Research Training Fellow at the International Centre for Circulatory Health (ICCH), National Heart and Lung Institute

(NHLI), St Mary’s Hospital, Imperial College Healthcare NHS Trust. Funded by a three year Clinical Research Training Fellowship from the British Heart Foundation

• March 2007 to January 2009: Academic Clinical NTN Cardiology and GIM (SpR), NW Thames, London Deanery

Investigator led research

• ‘Maximising clinical applicability of non-invasive methods for optimisation of cardiac pacemakers and effect of optimisation on cardiac efficiency’

      BHF Clinical Research Training Fellowship.

I compared the use of several non-invasive   methods in optimizing biventricular pacemakers. Through invasive experiments I demonstrated how CRT and atrioventricular optimization affect cardiac mechanoenergetics and coronary flow.

• ‘Assessment of right ventricular function during and following cardiac surgery and evaluation of pericardial physiology in preserving RV function’, BHF Project Grant. 

This project investigated the role of the pericardium on the function of the right ventricle following cardiac surgery.

Principal Co-Investigator in multicentre clinical research

• AVATAR – AF, HOPE – HF, EFFORTLESS, PROTECT-HF

Clinical Service Improvement

·        Co-ordinated the implementation of a web-based information packet for patients undergoing atrial fibrillation treatment at Harefield Hospital. The aim of this is to provide all the information needed by the patient, in a simple language. It aims at improving the understanding of their condition and the options available for their treatment (pharmacotherapy and ablative strategies)

·        Co-developed the procedure specific consent form for Atrial Fibrillation and Atrial tachycardia at the Royal Brompton and Harefield Hospitals

·       I was the lead Electrophysiology SpR at Imperial Healthcare NHS Trust for the London Ambulance Service (LAS) Arrhythmia Triaging Pilot Study (March – September 2013) which was driven by the arrhythmia workstream and LAS as part of the London Cardiovascular Project in line with the Model of Care document (published in 2010). This pilot study investigated the feasibility of 24/7 urgent provision of arrhythmia service and used a North/South of Thames divide for active and control arms. This pilot study yielded positive results with respect to timing of intervention and consequently the Primary Arrhythmia programme is now well established throughout London

Audit

• Ventricular Tachycardia Audit 2015-2023 Sheffield Teaching Hospitals NHS Foundation Trust

• Atrial Fibrillation Audit 2015-2023, Sheffield Teaching Hospitals NHS Foundation Trust

• Royal Brompton and Harefield Hospitals NHS Trust Atrial Fibrillation Audit, 2013-2014

• London Ambulance Service Primary Arrhythmia Audit; lead SpR at Imperial College Healthcare NHS Trust. March- September 2013

• ‘Management of Acute Coronary Syndrome’.  Central Middlesex Hospital, London 2005

• ‘Patient selection for Coronary Angiography’.  The General Hospital, St Helier, Jersey. Aimed at emphasizing the need for a second non invasive test, 2006

• ‘Management of patients with Alcohol abuse’. The General Hospital, St Helier, Jersey. Highlighted the need to add Pabrinex in the drug formulary, 2006

• ‘Hypertension in Chronic Kidney Disease is Highly Prevalent, Poorly Controlled And Related to Arterial Stiffening’. Department of Renal Medicine and Transplantation, St. George’s Hospital, London, UK, 2004

• ‘Recurrence of Focal Segmental Glomerulosclerosis (FSGS) in the renal allograft’. Department of Renal Medicine and Transplantation, St. George’s Hospital, London, UK, 2004                                                                                                                   

·          Director of the Intracardiac Echo Training course at The Northern General

Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK, 2024

• Honorary Senior Lecturer at Sheffield University, 2015 to date

• Faculty member of the MRCP PACES national course, STAR Centre, Harefield Hospital, 2014

·        Teach the Teacher Course, Oxford Medical, August 2013

·        Supervisor and mentor of Cardiovascular BSc projects at Imperial College (2009 – 2012)

·        Examiner of Cardiovascular BSc projects at Imperial College (2009 – 2012)

·        Teacher/tutor of undergraduate Imperial College medical students of the Electrophysiology module of the Cardiovascular BSc programme at Imperial College 2010-2013

·        Problem based learning (PBL) tutor for the graduate entry programme (GEP) students, St Georges Hospital, London, 2003-2004

1. Ablation versus anti-arrhythmic therapy for reducing all hospital episodes from recurrent atrial fibrillation: a prospective, randomized, multi-centre, open label trial.

Kanagaratnam P, McCready J, Tayebjee M, Shepherd E, Sasikaran T, Todd D, Johnson N, Kyriacou A, Hayat S, Hobson NA, Mann I, Balasubramaniam R, Whinnett Z, Earley M, Petkar S, Veasey R, Kirubakaran S, Coyle C, Kim MY, Lim PB, O'Neill J, Davies DW, Peters NS, Babalis D, Linton N, Falaschetti E, Tanner M, Shah J, Poulter N.

Europace. 2023 Mar 30;25(3):863-872. doi: 10.1093/europace/euac253.

2. Arrhythmic Burden and Outcomes in Pulmonary Arterial Hypertension.

Middleton JT, Maulik A, Lewis R, Kiely DG, Toshner M, Charalampopoulos A, Kyriacou A, Rothman A.

Front Med (Lausanne). 2019 Jul 23;6:169. doi: 10.3389/fmed.2019.00169.

3. Coronary Physiological Assessment in a Patient With Atrial Fibrillation: The Importance of Rhythm.

Mills MT, Kyriacou AL, Morris PD, Gunn JP.

JACC Cardiovasc Interv. 2021 Aug 9;14(15):1731-1733. doi: 10.1016/j.jcin.2021.05.035.

4. Effects of haemodynamically atrio-ventricular optimized His bundle pacing on heart failure symptoms and exercise capacity: the His Optimized Pacing Evaluated for Heart Failure (HOPE-HF) randomized, double-blind, cross-over trial.

Whinnett ZI, Shun-Shin MJ, Tanner M, Foley P, Chandrasekaran B, Moore P, Adhya S, Qureshi N, Muthumala A, Lane R, Rinaldi A, Agarwal S, Leyva F, Behar J, Bassi S, Ng A, Scott P, Prasad R, Swinburn J, Tomson J, Sethi A, Shah J, Lim PB, Kyriacou A, Thomas D, Chuen J, Kamdar R, Kanagaratnam P, Mariveles M, Burden L, March K, Howard JP, Arnold A, Vijayaraman P, Stegemann B, Johnson N, Falaschetti E, Francis DP, Cleland JGF, Keene D.

Eur J Heart Fail. 2023 Feb;25(2):274-283. doi: 10.1002/ejhf.2736.

5. Radiofrequency ablation of ventricular tachycardia in Anderson-Fabry disease: a case series.

Mills MT, Nelson TA, Kelland NF, Sahu J, Lee J, Lewis N, Hiwot T, Kyriacou AL.

Eur Heart J Case Rep. 2021 Feb 4;5(2):ytaa529. doi: 10.1093/ehjcr/ytaa529. eCollection 2021 Feb.

6. An exercise-based cardiac rehabilitation programme for AF patients in the NHS: a feasibility study.

Mills M, Johnson E, Zafar H, Horwood A, Lax N, Charlesworth S, Gregory A, Lee J, Sahu J, Kirkwood G, Kelland N, Kyriacou A.

Br J Cardiol. 2020 Jun 11;27(2):20. doi: 10.5837/bjc.2020.020. eCollection 2020.

7. Sinus tachycardia and long-COVID: An opportunity in the challenge.

Al-Mohammad A, Kyriacou AL.

J R Coll Physicians Edinb. 2023 Dec;53(4):312-313. doi: 10.1177/14782715231213896. Epub 2023 Nov 22.

8. Meta-analysis of echocardiographic quantification of left ventricular filling pressure.

Jones R, Varian F, Alabed S, Morris P, Rothman A, Swift AJ, Lewis N, Kyriacou A, Wild JM, Al-Mohammad A, Zhong L, Dastidar A, Storey RF, Swoboda PP, Bax JJ, Garg P.

ESC Heart Fail. 2021 Feb;8(1):566-576. doi: 10.1002/ehf2.13119. Epub 2020 Nov 23.

9. A systematic approach to designing reliable VV optimization methodology: assessment of internal validity of echocardiographic, electrocardiographic and haemodynamic optimization of cardiac resynchronization therapy.

Kyriacou A, Li Kam Wa ME, Pabari PA, Unsworth B, Baruah R, Willson K, Peters NS, Kanagaratnam P, Hughes AD, Mayet J, Whinnett ZI, Francis DP.

Int J Cardiol. 2013 Aug 10;167(3):954-64. doi: 10.1016/j.ijcard.2012.03.086. Epub 2012 Mar 27.

10. Cardiac resynchronization therapy is certainly cardiac therapy, but how much resynchronization and how much atrioventricular delay optimization?

Kyriacou A, Pabari PA, Francis DP.

Heart Fail Rev. 2012 Nov;17(6):727-36. doi: 10.1007/s10741-011-9271-1.

11. Applicability of the iterative technique for cardiac resynchronization therapy optimization: full-disclosure, 50-sequential-patient dataset of transmitral Doppler traces, with implications for future research design and guidelines.

Jones S, Shun-Shin MJ, Cole GD, Sau A, March K, Williams S, Kyriacou A, Hughes AD, Mayet J, Frenneaux M, Manisty CH, Whinnett ZI, Francis DP.

Europace. 2014 Apr;16(4):541-50. doi: 10.1093/europace/eut257. Epub 2013 Sep 25.

12. Variation in optimal hemodynamic atrio-ventricular delay of biventricular pacing with different endocardial left ventricular lead locations using precision hemodynamics.

Butcher CJT, Cantor E, Sohaib A, Shun-Shin MJ, Haynes R, Khan H, Kyriacou A, Shi R, Chen Z, Haldar S, Cleland JGF, Hussain W, Markides V, Jones DG, Lane RE, Mason MJ, Whinnett ZI, Francis DP, Wong T.

J Cardiovasc Electrophysiol. 2023 Jun;34(6):1431-1440. doi: 10.1111/jce.15862. Epub 2023 May 26.

13. When is an optimization not an optimization? Evaluation of clinical implications of information content (signal-to-noise ratio) in optimization of cardiac resynchronization therapy, and how to measure and maximize it.

Pabari PA, Willson K, Stegemann B, van Geldorp IE, Kyriacou A, Moraldo M, Mayet J, Hughes AD, Francis DP.

Heart Fail Rev. 2011 May;16(3):277-90. doi: 10.1007/s10741-010-9203-5.

14. Evaluation of subcutaneous implantable cardioverter-defibrillator performance in patients with ion channelopathies from the EFFORTLESS cohort and comparison with a meta-analysis of transvenous ICD outcomes.

Lambiase PD, Eckardt L, Theuns DA, Betts TR, Kyriacou AL, Duffy E, Knops R.

Heart Rhythm O2. 2020 Oct 28;1(5):326-335. doi: 10.1016/j.hroo.2020.10.002. eCollection 2020 Dec.

15. Predictors of the efficacy of His bundle pacing in patients with a prolonged PR interval: A stratified analysis of the HOPE-HF randomized controlled trial.

Keene D, Kaza N, Srinivasan D, Ali N, Tanner M, Foley P, Chandrasekaran B, Moore P, Adhya S, Qureshi N, Muthumala A, Lane R, Rinaldi A, Agarwal S, Leyva F, Behar J, Bassi S, Ng A, Scott P, Prasad R, Swinburn J, Tomson J, Sethi A, Shah J, Lim PB, Kyriacou A, Thomas D, Chuen J, Kamdar R, Kanagaratnam P, Mariveles M, Johnson N, Falaschetti E, Howard JP, Arnold A, Cleland JGF, Francis DP, Whinnett Z, Shun-Shin M.

Eur J Heart Fail. 2024 Jul 18. doi: 10.1002/ejhf.3367.

16. Improvement in coronary blood flow velocity with acute biventricular pacing is predominantly due to an increase in a diastolic backward-travelling decompression (suction) wave.

Kyriacou A, Whinnett ZI, Sen S, Pabari PA, Wright I, Cornelussen R, Lefroy D, Davies DW, Peters NS, Kanagaratnam P, Mayet J, Hughes AD, Francis DP, Davies JE.

Circulation. 2012 Sep 11;126(11):1334-44. doi: 10.1161/CIRCULATIONAHA.111.075606. Epub 2012 Aug 1.

17. Selective right ventricular impairment following coronary artery bypass graft surgery.

Yadav H, Unsworth B, Fontana M, Diller GP, Kyriacou A, Baruah R, Mayet J, Francis DP.

Eur J Cardiothorac Surg. 2010 Feb;37(2):393-8. doi: 10.1016/j.ejcts.2009.08.004. Epub 2009 Sep 15.

18. Improving haemodynamic optimization of cardiac resynchronization therapy for heart failure.

Sharp AJ, Sohaib SMA, Shun-Shin MJ, Pabari P, Willson K, Rajkumar C, Hughes AD, Kanagaratnam P, Mayet J, Whinnett ZI, Kyriacou AA, Francis DP.

Physiol Meas. 2019 May 1;40(4):04NT01. doi: 10.1088/1361-6579/ab152c.

19. Prescribing dronedarone for paroxysmal atrial fibrillation: how is it done across the UK and is it safe?

Yones E, Mullan J, Horwood A, Connell N, Odams S, Maloney J, Kyriacou AL, Sahu J, Lee JM, Kelland NF.

Eur J Hosp Pharm. 2019 Jul;26(4):220-222. doi: 10.1136/ejhpharm-2017-001207. Epub 2017 May 12.

20. Distinct impacts of heart rate and right atrial-pacing on left atrial mechanical activation and optimal AV delay in CRT.

Kyriacou A, Rajkumar CA, Pabari PA, Sohaib SMA, Willson K, Peters NS, Lim PB, Kanagaratnam P, Hughes AD, Mayet J, Whinnett ZI, Francis DP.

Pacing Clin Electrophysiol. 2018 Jun 1;41(8):959-66. doi: 10.1111/pace.13401.

21. British randomised controlled trial of AV and VV optimization ("BRAVO") study: rationale, design, and endpoints.

Whinnett ZI, Sohaib SM, Jones S, Kyriacou A, March K, Coady E, Mayet J, Hughes AD, Frenneaux M, Francis DP; BRAVO Investigators.

BMC Cardiovasc Disord. 2014 Apr 3;14:42. doi: 10.1186/1471-2261-14-42.

22. Multicenter Randomized Controlled Crossover Trial Comparing Hemodynamic Optimization Against Echocardiographic Optimization of AV and VV Delay of Cardiac Resynchronization Therapy: The BRAVO Trial.

Whinnett ZI, Sohaib SMA, Mason M, Duncan E, Tanner M, Lefroy D, Al-Obaidi M, Ellery S, Leyva-Leon F, Betts T, Dayer M, Foley P, Swinburn J, Thomas M, Khiani R, Wong T, Yousef Z, Rogers D, Kalra PR, Dhileepan V, March K, Howard J, Kyriacou A, Mayet J, Kanagaratnam P, Frenneaux M, Hughes AD, Francis DP.

JACC Cardiovasc Imaging. 2019 Aug;12(8 Pt 1):1407-1416. doi: 10.1016/j.jcmg.2018.02.014. Epub 2018 May 16.

23. Fully automatable, reproducible, noninvasive simple plethysmographic optimization: proof of concept and potential for implantability.

Kyriacou A, Pabari PA, Whinnett ZI, Arri S, Willson K, Baruah R, Stegemann B, Mayet J, Kanagaratnam P, Hughes AD, Francis DP.

Pacing Clin Electrophysiol. 2012 Aug;35(8):948-60. doi: 10.1111/j.1540-8159.2012.03435.x. Epub 2012 Jul 2.

PMID: 22747698 Clinical Trial.

24. Novel cardiac pacemaker-based human model of periodic breathing to develop real-time, pre-emptive technology for carbon dioxide stabilisation.

Baruah R, Giannoni A, Willson K, Manisty CH, Mebrate Y, Kyriacou A, Yadav H, Unsworth B, Sutton R, Mayet J, Hughes AD, Francis DP.

Open Heart. 2014 Aug 12;1(1):e000055. doi: 10.1136/openhrt-2014-000055. eCollection 2014.

25. Cardiac resynchronization therapy: mechanisms of action and scope for further improvement in cardiac function.

Jones S, Lumens J, Sohaib SMA, Finegold JA, Kanagaratnam P, Tanner M, Duncan E, Moore P, Leyva F, Frenneaux M, Mason M, Hughes AD, Francis DP, Whinnett ZI; BRAVO Investigators.

Europace. 2017 Jul 1;19(7):1178-1186. doi: 10.1093/europace/euw136.

26. Atrial flutter and fibrillation in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension in the ASPIRE registry: Comparison of rate versus rhythm control approaches.

Sammut MA, Condliffe R, Elliot C, Hameed A, Lewis R, Kiely DG, Kyriacou A, Middleton JT, Raithatha A, Rothman A, Thompson AAR, Turner R, Charalampopoulos A.

Int J Cardiol. 2023 Jan 15;371:363-370. doi: 10.1016/j.ijcard.2022.09.031. Epub 2022 Sep 18.

27. Atrioventricular delay optimization of cardiac resynchronisation therapy: comparison of non-invasive blood pressure with invasive haemodynamic measures.

Finegold J, Bordachar P, Kyriacou A, Sohaib SM, Kanagaratnam P, Ploux S, Lim B, Peters N, Davies W, Ritter P, Francis DP, Whinnett ZI.

Int J Cardiol. 2015 Feb 1;180:221-2. doi: 10.1016/j.ijcard.2014.11.129. Epub 2014 Nov 25.

28. Noninvasive electrocardiographic mapping to guide ablation of outflow tract ventricular arrhythmias.

Jamil-Copley S, Bokan R, Kojodjojo P, Qureshi N, Koa-Wing M, Hayat S, Kyriacou A, Sandler B, Sohaib A, Wright I, Davies DW, Whinnett Z, S Peters N, Kanagaratnam P, Lim PB.

Heart Rhythm. 2014 Apr;11(4):587-94. doi: 10.1016/j.hrthm.2014.01.013. Epub 2014 Jan 17.

29. Cardiac resynchronization therapy and AV optimization increase myocardial oxygen consumption, but increase cardiac function more than proportionally.

Kyriacou A, Pabari PA, Mayet J, Peters NS, Davies DW, Lim PB, Lefroy D, Hughes AD, Kanagaratnam P, Francis DP, Whinnett ZI.

Int J Cardiol. 2014 Feb 1;171(2):144-52. doi: 10.1016/j.ijcard.2013.10.026. Epub 2013 Oct 16.

30. Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation.

Mills MT, Grafton-Clarke C, Williams G, Gosling RC, Al Baraikan A, Kyriacou AL, Morris PD, Gunn JP, Swoboda PP, Levelt E, Tsampasian V, van der Geest RJ, Swift AJ, Greenwood JP, Plein S, Vassiliou V, Garg P.

Wellcome Open Res. 2021 May 18;6:73. doi: 10.12688/wellcomeopenres.16655.2. eCollection 2021.

31. Effect of coronary artery bypass surgery on myocardial function as assessed by tissue Doppler echocardiography.

Diller GP, Wasan BS, Kyriacou A, Patel N, Casula RP, Athanasiou T, Francis DP, Mayet J.

Eur J Cardiothorac Surg. 2008 Nov;34(5):995-9. doi: 10.1016/j.ejcts.2008.08.008. Epub 2008 Oct 1.

32. Evidence that conflict regarding size of haemodynamic response to interventricular delay optimization of cardiac resynchronization therapy may arise from differences in how atrioventricular delay is kept constant.

Sohaib SM, Kyriacou A, Jones S, Manisty CH, Mayet J, Kanagaratnam P, Peters NS, Hughes AD, Whinnett ZI, Francis DP.

Europace. 2015 Dec;17(12):1823-33. doi: 10.1093/europace/euu374. Epub 2015 Apr 7.

33. The right ventricular annular velocity reduction caused by coronary artery bypass graft surgery occurs at the moment of pericardial incision.

Unsworth B, Casula RP, Kyriacou AA, Yadav H, Chukwuemeka A, Cherian A, Stanbridge Rde L, Athanasiou T, Mayet J, Francis DP.

Am Heart J. 2010 Feb;159(2):314-22. doi: 10.1016/j.ahj.2009.11.013.

34. Dissociated pulmonary vein potentials: Expression of the cardiac autonomic nervous system following pulmonary vein isolation?

Kyriacou A, Hayat S, Qureshi N, Peters NS, Kanagaratnam P, Lim PB.

HeartRhythm Case Rep. 2015 Sep 4;1(6):401-405. doi: 10.1016/j.hrcr.2015.02.009. eCollection 2015 Nov.

35. Multinational evaluation of the interpretability of the iterative method of optimisation of AV delay for CRT.

Raphael CE, Kyriacou A, Jones S, Pabari P, Cole G, Baruah R, Hughes AD, Francis DP.

Int J Cardiol. 2013 Sep 20;168(1):407-13. doi: 10.1016/j.ijcard.2012.09.097. Epub 2012 Oct 13.

·  LGE MRI ischaemic scar tgradient predicts inducible ventricular arrhythmia. S Jamil-Copley, W Bai, B Ariff, PB Lim, M Koa-Wing, A Kyriacou, S Hayat, A Sohaib, N Qureshi, B Sandler, D O'Regan, Z Whinnett, W Davies, D Rueckert, P Kanagaratnam, N Peters. HRC 2013. Europace (2013) 15 (suppl 4): iv9-iv13

·  Non-invasive electrocardiographic mapping to guide ablation of outflow tract ventricular arrhythmias: pre-procedural localisation accuracy. S Jamil-Copley, B Ryan, P Kojodjojo, N Qureshi, M Koa-Wing, S Hayat, A Kyriacou, B Sandler, A Sohaib, I Wright, W Davies, N Peters, Z Whinnett, P Kanagaratnam, PB Lim. HRC 2013. Europace (2013) 15 (suppl 4): iv14-iv18

·   Low voltage areas in atrial fibrillation do not correlate to LGE-MRI defined scar in patients with persistent atrial fibrillation. N A Qureshi, W Bai, B Ariff, A Williams, C Monro, S Kim, S Jamil-Copley, S Hayat, M Kao-Wing, A Kyriacou, B Sandler,NS Fu, P Kanagaratnam, Z Whinnett, DW Davies, D Lefroy, NS Peters, PB Lim. HRC 2013. Europace (2013) 15 (suppl 4): iv14-iv18

·  First-in-man evidence of the mechanistic effects of biventricular pacing on coronary physiologyOriginal Text. Kyriacou A, Whinnett ZI, Davies JE, Pabari PA, Peters NS, Kanagaratnam P, Mayet J, Hughes AD, Francis DP. The Lancet, Volume 381, Issue Page S62, 27 February 2013, doi:10.1016/S0140-6736(13)60502-4. Medical Research Society, UK. Rafferty Prize in Cardiovascular Sciences – Finalist 2013

·   Is the Long Term Prognostic Benefit of Primary Angioplasty in the 'Real World' Statistically Lacking? An Analysis of 54,360 Patients with ST Elevation Myocardial Infarction. Sen S, Francis DP, Tillin T, Foale RA, Malik I, Mikhail GW, Hadjiloizou N, Baruah R, Kyriacou A, Hughes AD, Mayet J, Davies JE. Circulation. 2010;122:A16715

·  Timely Modulation of Cardiac Output by a Pacemaker Can Stabilize Induced Periodic Breathing. Baruah R, Giannoni A, Willson K, Manisty CH, Fontana M, Mebrate Y, Yadav H, Unsworth B, Kyriacou A, Sen S, Sutton R, Kanagaratnam P, Hughes AD, Mayet J, and Francis DP. Circulation. 2010;122:A19770.

·   Optimization of VV delay of CRT is more reproducible using peak velocities than using velocity time integral, as well as being quicker. Pabari PA, Kyriacou A, Moraldo M,  Hughes AD, Mayet J, Francis DP. J Am Coll Cardiol. 2011;57(14s1):E802-E802. doi:10.1016/S0735-1097(11)60802-4

·  VTI ratio is both more variable and more time-consuming than peak velocity in calculating aortic valve area. R. Baruah, C. Raphael, S. Rizvi, B. Unsworth, S. Sen, A. Kyriacou, P. Pabari, J. Mayet, N. Sutaria, D.P. Francis. European Heart Journal ( 2010 ) 31 ( Abstract Supplement ), 3-4

·  Periodic Breathing: novel dynamic therapies for a dynamic condition. Baruah R, Giannoni A, Manisty CH,  Willson K, Mebrate Y, Kyriacou A, Sen S, Shanmuganathan M,  Unsworth B, Yadav H, Davies JE,   Sutton R, Mayet J, Hughes AD, Francis DP. Heart 2010 Jun; 9(Suppl 1) 1-145

·  Timely modulation of cardiac output by a pacemaker can stabilize oscillations in ventilation. Baruah R, Giannoni A, Manisty CH,  Willson K, Mebrate Y, Kyriacou A, Sen S, Dhutia N, Pabari, P, Hadjiloizou N, Moraldo M, Yadav H,  Unsworth B, Kanagaratnam P, Sutton R, Mayet J, Francis DP. Heart rhythm May 2010;  7 (5) S382-S445

·  Adaptation of non-invasive haemodynamic technologies and development of algorithms for cost effective, automated optimisation of cardiac resynchronisation devices. A Kyriacou, Z.I. Whinnett, P.A. Pabari, K. Willson, D. Lefroy, D.W. Davies, N.S. Peters, J. Mayet, P. Kanagaratnam, D.P. Francis. European Heart Journal ( 2010 ) 31 ( Abstract Supplement ), 418

·  Feasibility of the iterative method of qualitative optimisation of AV delay for CRT: a multinational evaluation. C.E. Raphael, A. Kyriacou, P. Pabari, R. Baruah, G. Cole, A.D. Hughes, D.P. Francis. European Heart Journal ( 2011 ) 32 ( Abstract Supplement ), 337-338

·  The effect of cardiac resynchronization therapy and of atrioventricular delay optimization on mechanoenergetic efficiency: simply, a better value for money. A. Kyriacou, P. Pabari, I. Wright, R. Cornellussen, S. Sen, J. Mayet, N. Peters, P. Kanagaratnam, Z. Whinnett, D.P. Francis. European Heart Journal ( 2011 ) 32 ( Abstract Supplement ), 151

·  Invasive evaluation of whether decline in pressure after initial immediate increment on improving AV delay of CRT is due to vasodilatation or decline in cardiac function. P.A.Pabari, A. Kyriacou, Z.I. Whinnett, I. Wright, K. Willson, J. Mayet, A.D. Hughes, D.P. Francis. European Heart Journal ( 2011 ) 32 ( Abstract Supplement ), 782

·  Utility of Intraclass Correlation Coefficient to quantify efficiency of optimization markers. A Kyriacou, ZI Whinnett, PA Pabari, R Baruah, D Lefroy, NS Peters, DW Davies, P Kanagaratnam, J Mayet, DP Francis,. European Journal of Heart Failure Supplements (2010) 9, S74

·  Applicability of low cost oximeter-type plethysmography as an alternative to volume clamp (Finapres-type) plethysmography in biventrivular pacemaker optimization. A Kyriacou, ZI Whinnett, PA Pabari, R Baruah, D Lefroy, DW Davies, NS Peters, P Kanagaratnam, J Mayet, DP Francis. European Journal of Heart Failure Supplements (2010) 9, S21

·  Relative contribution of heart rate regularization, versus heart rate increase, to improved consistency of optimization of pacemakers at higher paced heart rates. A Kyriacou, PA Pabari, ZI Whinnett, R Baruah, D Lefroy, NS Peters, DW Davies, J Mayet, P Kanagartnam, DP Francis. European Journal of Heart Failure Supplements (2010) 9, S22

·   Dyssynchronous heart failure and biventricular pacing uniquely expose the intricate relationship between myocardial function and coronary flow: First-in-human evidence of how pacing affects coronary physiology. A. Kyriacou, J.E. Davies, S. Sen, P.A. Pabari, I. Wright, J. Mayet, D. Lefroy, W.D. Davies, N.S. Peters, P. Kanagaratnam, D.P. Francis Z.I. Whinnett, Europace (2012) 14 (suppl 4): iv1-iv3

·   Simultaneous invasive pressure and flow measurements during AV delay improvement reveal a compensatory peripheral vasodilator response which attenuates the initial blood pressure increment: implications for the design of optimization protocols. P A Pabari, A Kyriacou, I Wright, A D Hughes, J Mayet, Z I Whinnett, D P Francis, C H Manisty. doi:10.1136/heartjnl-2012-301877b.4  May 2012 Volume 98 Supplement 1

·   Validating markers of mechanical dyssynchrony by experimental manipulation of interventricular timings: what is needed to make them a reasonable prospect for cardiac resynchronization therapy selection? P A Pabari, M Moraldo, A D Hughes, J Mayet, A Kyriacou, D P Francis, C H Manisty. doi:10.1136/heartjnl-2012-301877b.3 May 2012 Volume 98 Supplement 1

·   Improvement in coronary blood flow velocity with acute biventricular pacing is predominantly due to an increase in a diastolic backward-travelling decompression (suction) wave. A Kyriacou, Z I Whinnett, S Sen, P Pabari, D W Davies, N S Peters, P Kanagaratnam, J Mayet, A D Hughes, D P Francis, J E Davies. doi:10.1136/heartjnl-2012-301877b.6 May 2012 Volume 98 Supplement 1

·   Should current modalities of VV optimization be trusted? An assessment of the internal validity of echocardiographic, electrocardiographic and haemodynamic modalities of optimization. A Kyriacou, M Li Kam Wa, P Pabari, P Kanagaratnam, N S Peters, J Mayet, D P Francis, Z I Whinnett. doi:10.1136/heartjnl-2012-301877b.7 May 2012 Volume 98 Supplement 1

·  CRT optimization: improving echocardiographic techniques by accommodating biological variability within different echocardiographic parameters. P A Pabari, A Kyriacou, M Moraldo, B Unsworth, N Sutaria, J Mayet, A D Hughes, DP Francis. doi:10.1136/heartjnl-2011-300198.116 June 2011 Volume 97 Supplement 1

·  Evaluation of the impact of AV delay variation on the acute mechanoenergetic efficiency of cardiac resynchronization therapy and assessment of performance of non-invasive Vs invasive haemodynamic optimization. A Kyriacou, P Pabari, K Willson, R Baruah, S Sayan, D W Davies, J Mayet, N S Peters, P Kanagaratnam, Z Whinnett, D P Francis. doi:10.1136/heartjnl-2011-300198.88 June 2011 Volume 97 Supplement 1

·  Increasing The Heart Rate Shortens The Optimal AV Delay, But Enlarges The Difference In The Optimal AV Delay Between Sensed And Paced Atrium.  A Kyriacou, CA Rajkumar, PA. Pabari, WD Davies, NS Peters, P Kanagaratnam, AD Hughes, J Mayet, DP Francis, ZI Whinnett. Heart Rhythm 2012, Volume 9, Supplement 5

·  Increased Diastolic Microcirculatory Suction, As Evidenced By The Backward-travelling Decompression Wave, Is The Predominant Driver For The Improvement In Coronary Blood Flow With Biventricular Pacing. A Kyriacou, ZI Whinnett, S Sen, PA Pabari, I Wright, R Cornelussen, WD Davies, NS Peters, P Kanagaratnam, J Mayet, AD Hughes, DP Francis, JE Davies, Heart Rhythm 2012, Volume 9, Supplement 5

·  Anaemia is highly prevalent in Diabetic Nephropathy and possibly related to the malnutrition-inflammation complex A Kyriacou, S Mir, M Chowrimootoo, C Streather, S Nelson, D Banerjee. American Diabetes Association. June 2005 Diabetes Journal Supplement

 ·   Hypertension in Chronic Kidney Disease is Highly Prevalent, Poorly Controlled And Related to Arterial Stiffening S Mir, A Kyriacou, M Chowrimootoo, C Streather, S Nelson, D Banerjee. British Renal Association Congress April 2005